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Targeted Allele Detail
Symbol: Iqgap2tm1Vs
Name: IQ motif containing GTPase activating protein 2; targeted mutation 1, Valentina A Schmidt
MGI ID: MGI:3526416
Gene: Iqgap2  Location: Chr13:95763685-96028788 bp, - strand  Genetic Position: Chr13, 50.26 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:132670
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 36,241 bp genomic fragment spanning exons 18 - 31 was replaced with a PGK-neo cassette via homologous recombination. This resulted in removal of part of the IQ2 and all of the IQ3, IQ4, and GRD motifs. QRT-PCR confirmed the absence of transcript in hepatocytes and immunoblot analysis confirmed the absence of protein in liver, spleen, heart, and kidney lysates. Only in the liver was a modest increase in Iqgap1 expression detected. QRT-PCR analysis did not detect any change in F2rl2 (coding sequence contained within intron 13 of Iqgap2) expression. (J:132670)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Iqgap2 Mutation:  56 strains or lines available
Original:  J:132670 Schmidt VA, et al., Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol Cell Biol. 2008 Mar;28(5):1489-502
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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