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Tmprss2tm1Psn
Targeted Allele Detail
Nomenclature
Symbol: Tmprss2tm1Psn
Name: transmembrane protease, serine 2; targeted mutation 1, Peter Nelson
MGI ID: MGI:3526414
Synonyms: Tmprss2-, Tmprss2tm1Tsyk
Gene: Tmprss2  Location: Chr16:97564682-97611195 bp, - strand  Genetic Position: Chr16, 57.53 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105558
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 10-13 with a loxP-flanked neo. The deleted exons encode 2 of 3 catalytic residues essential for serine protease activity. Quantitative RT-PCR failed to detect transcript of exons 11 and 13. Mutants expressed only a 20% reduction in transcripts spanning exons 3 and 4 or 5 and 6, however, mutants expressed 80% less transcript of the 3' UTR than wild-type mice. Sequencing revealed that mutant transcripts alternatively splice exon 9 to exon 14. (J:105558)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 23 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmprss2 Mutation:  23 strains or lines available
References
Original:  J:105558 Kim TS, et al., Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol. 2006 Feb;26(3):965-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory