Ctsgtm2.1(PML/RARA)Ley
Targeted Allele Detail
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Symbol: |
Ctsgtm2.1(PML/RARA)Ley |
Name: |
cathepsin G; targeted mutation 2.1, Timothy J Ley |
MGI ID: |
MGI:3526413 |
Synonyms: |
Ctsgtm2.1Ley, mCGPML-RARalpha, mCGPR(deltaPGK-neo), PRWT |
Gene: |
Ctsg Location: Chr14:56337342-56340031 bp, - strand Genetic Position: Chr14, 28.19 cM
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Alliance: |
Ctsgtm2.1(PML/RARA)Ley page
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Germline Transmission: |
Earliest citation of germline transmission:
J:84230
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Ctsgtm2.1(PML/RARA)Ley expresses
2 genes
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PML (5371) |
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human |
RARA (5914) |
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Mutation details: A human cDNA encoding the PML-RARalpha fusion and a loxP flanked PGK-neo was inserted into the 5' UTR. Transient Cre expression removed the floxed PGK-neo.
(J:84230)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ctsg Mutation: |
13 strains or lines available
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Original: |
J:84230 Westervelt P, et al., High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood. 2003 Sep 1;102(5):1857-65 |
All: |
17 reference(s) |
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