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Targeted Allele Detail
Symbol: Flnctm1Lmk
Name: filamin C, gamma; targeted mutation 1, Louis M Kunkel
MGI ID: MGI:3526406
Gene: Flnc  Location: Chr6:29433256-29461883 bp, + strand  Genetic Position: Chr6, 12.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:112170
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neomycin selection cassette replaced 4.1kb of the gene, including the last eight exons (41-48). Western blot analysis on muscle lysates derived from homozygous mice indicated that a truncated protein is expressed at low levels from this allele. (J:112170)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flnc Mutation:  4 strains or lines available
Original:  J:112170 Dalkilic I, et al., Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure. Mol Cell Biol. 2006 Sep;26(17):6522-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory