Glrx^tm1Ysh
Targeted Allele Detail

Summary

• Symbol: Glrx^tm1Ysh
• Name: glutaredoxin; targeted mutation 1, Ye-Shih Ho
• MGI ID: MGI:3526399
• Synonyms: Glrx1^-, Glrx^tm2Ysh, GRX-null
• Gene: Glrx Location: Chr13:75988004-75998270 bp, + strand Genetic Position: Chr13, 40.95 cM
• Alliance: Glrx^tm1Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112896
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. Absence of protein product was confirmed by northern and western blot analysis of brain, heart, kidney, liver and lung tissue. (J:112896, J:125192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glrx Mutation: 13 strains or lines available

References

• Original: J:112896 Reynaert NL, et al., Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13086-91
• All: 21 reference(s)