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Gene trapped Allele Detail
Symbol: Abcc4Gt(RRC212)Byg
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; gene trap RRC212, BayGenomics
MGI ID: MGI:3526359
Synonyms: mrp4-
Gene: Abcc4  Location: Chr14:118482692-118706219 bp, - strand  Genetic Position: Chr14, 62.24 cM
Mutant Cell Line:  RRC212
Germline Transmission:  Earliest citation of germline transmission: J:139829
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
Mutation detailsThe gene trap vector, pGT1lxf, inserted between exon 18 and exon 19. RT-PCR and western blot analysis confirm the absence of mTNA and protein expression in homozygous MEFs. (J:139829)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc4 Mutation:  121 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:139829 Lin ZP, et al., Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Mol Pharmacol. 2008 Jan;73(1):243-51
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory