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Abcc4Gt(RRC212)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Abcc4Gt(RRC212)Byg
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; gene trap RRC212, BayGenomics
MGI ID: MGI:3526359
Synonyms: mrp4-
Gene: Abcc4  Location: Chr14:118482692-118706219 bp, - strand  Genetic Position: Chr14, 62.24 cM
Mutation
origin
Mutant Cell Line:  RRC212
Germline Transmission:  Earliest citation of germline transmission: J:139829
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector, pGT1lxf, inserted between exon 18 and exon 19. RT-PCR and western blot analysis confirm the absence of mTNA and protein expression in homozygous MEFs. (J:139829)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc4 Mutation:  121 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:139829 Lin ZP, et al., Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Mol Pharmacol. 2008 Jan;73(1):243-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory