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Hmox1tm1.1Gkl
Targeted Allele Detail
Nomenclature
Symbol: Hmox1tm1.1Gkl
Name: heme oxygenase 1; targeted mutation 1.1, George Kollias
MGI ID: MGI:3526228
Synonyms: Hmox1FL
Gene: Hmox1  Location: Chr8:75093621-75100589 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Hmox1tm1.1Gkl/Hmox1tm1.1Gkl Lyz2tm1(cre)Ifo/Lyz2+ mice show decreased susceptibility to L. monocytogenes infection

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:148498
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 2, and an additional loxP site was inserted downstream of exon 4. Germ line, cre mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed.
Generation of Hmox1tm1.1Gkl and Hmox1tm1.2Gkl alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  10 strains or lines available
Notes
ES cell line = "129/3."
References
Original:  J:148498 Tzima S, et al., Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med. 2009 May 11;206(5):1167-79
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory