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Sycp2tm1Jw
Targeted Allele Detail
Nomenclature
Symbol: Sycp2tm1Jw
Name: synaptonemal complex protein 2; targeted mutation 1, Jeremy Wang
MGI ID: MGI:3526164
Gene: Sycp2  Location: Chr2:178345293-178407685 bp, - strand  Genetic Position: Chr2, 99.81 cM, cytoband H4
Meiotic arrest and apoptosis of spermatocytes in Sycp2tm1Jw/Sycp2tm1Jw mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111287
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExons 39-43 were replaced by the PGK1-Neo selection marker. RT-PCR demonstrated expression of a transcript resulting from exon 38 splicing to exon 44. Protein was expressed in mutants, resulting from the shorter, mutant transcript. (J:111287)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sycp2 Mutation:  4 strains or lines available
References
Original:  J:111287 Yang F, et al., Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol. 2006 May 22;173(4):497-507
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory