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Rai1tm1Jrl
Targeted Allele Detail
Nomenclature
Symbol: Rai1tm1Jrl
Name: retinoic acid induced 1; targeted mutation 1, James R Lupski
MGI ID: MGI:3526160
Synonyms: Rai1-
Gene: Rai1  Location: Chr11:60105013-60199197 bp, + strand  Genetic Position: Chr11, 37.81 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98073
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn approximately 4.0 kb of the coding region in exon 2 was replaced by an intra-ribosomal entry site IRES-lacZ-pA cassette followed by a loxP flanked PGKneobpA cassette. RT-PCR indicated that only sequence 5' of the deleted region was present in transcripts. This truncation eliminates all nuclear localization regions and the PHD domain. (J:98073)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 65 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rai1 Mutation:  35 strains or lines available
References
Original:  J:98073 Bi W, et al., Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome. Hum Mol Genet. 2005 Apr 15;14(8):983-95
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory