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Targeted Allele Detail
Symbol: Ep300tm2Pkb
Name: E1A binding protein p300; targeted mutation 2, Paul K Brindle
MGI ID: MGI:3526150
Synonyms: p300flox
Gene: Ep300  Location: Chr15:81470329-81536278 bp, + strand  Genetic Position: Chr15, 38.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:105505
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 9 is flanked by LoxP sites (in same orientation). There also is one Frt site 3' of exon 9 left from removal of selection cassette. Absence of transcription and translation products was confirmed by QRT-PCR, immunohistochemistry, and Western blot analysis. (J:105505)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ep300 Mutation:  64 strains or lines available
Original:  J:105505 Kasper LH, et al., Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol. 2006 Feb;26(3):789-809
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory