Ceat1^NOD
QTL Variant Detail

Summary

• QTL variant: Ceat1^NOD
• Name: chronic experimental autoimmune thyroiditis 1; NOD
• MGI ID: MGI:3526131
• QTL: Ceat1 Location: Chr17:12636682-26401133 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 8.51 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: NOD

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to chronic experimental autoimmune thyroiditis compared to CBA/J. (J:77545)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:77545

Idd16 (18 cM) on mouse Chromosome 17 was determined to be separate and distinct from the H2 locus (23 cM) using recombinant congenic strains. A recombinant congenic strain carrying C57BL/6J-derived DNA from D17Mit199 (16.9 cM) to D17Mit16 (17.4 cM), which excludes the H2 locus, on an NOD diabetes susceptible background is resistant to diabetes. Therefore, the Idd16 locus maps proximal to and does not include H2.

Genome scan was used to identify QTLs for thyroiditis. A population of 183 (NOD-H2^k x CBA/J)F2 animals were typed for 81 polymorphic loci. Chronic experimental autoimmune thyroiditis was induced in 6- and 8-weeks old animals. Animals were sacrificed and thyroids were examined for the presence of mononuclear cell infiltrates in clusters or foci. A significant locus named Ceat1 (chronic experimental autoimmune thyroiditis 1) was identified at 11 cM on mouse Chromosome 17 near D17Mit114 and is linked to both cluster and foci phenotypes. This locus spans an 8 cM region between D17Mit114 and D17Mit100 and shows overlap with Idd16. NOD-derived alleles appear to confer dominant susceptibility to thyroiditis at Ceat1.

Suggestive linkage to thyroiditis mapped to 9 cM on mouse Chromosome 5 near D5Mit72 (P=0.015) and to 5.5 cM on mouse Chromosome 7 near D7Mit20 (P=0.005). The D5Mit72 locus shows linkage to the cluster phenotype with recessive inheritance, and the D7Mit20 locus shows linkage to the foci phenotype with a dominant mode of inheritance.

References

• Original: J:77545 Boulard O, et al., An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice. Diabetes. 2002 Jul;51(7):2141-7
• All: 1 reference(s)