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Ghrtm2Mwat
Targeted Allele Detail
Nomenclature
Symbol: Ghrtm2Mwat
Name: growth hormone receptor; targeted mutation 2, Michael J Waters
MGI ID: MGI:3526105
Synonyms: m391
Gene: Ghr  Location: Chr15:3317760-3583492 bp, - strand  Genetic Position: Chr15, 1.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95149
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA targeting vector was designed to result in truncation of the protein at lysine 391. Northern blot of hepatic tissue confirmed successful targeting. (J:95149)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ghr Mutation:  20 strains or lines available
References
Original:  J:95149 Rowland JE, et al., In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol Cell Biol. 2005 Jan;25(1):66-77
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory