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Targeted Allele Detail
Symbol: Kat5tm1Jwl
Name: K(lysine) acetyltransferase 5; targeted mutation 1, John W Lough
MGI ID: MGI:3526095
Synonyms: Tip60-
Gene: Kat5  Location: Chr19:5603017-5610094 bp, - strand  Genetic Position: Chr19, 4.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:125164
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting vector replaced 2,787 bp, including 193 bp of the promoter and exons 1-9, with the neomycin-resistance cassette in reverse orientation. (J:125164, J:153728)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kat5 Mutation:  3 strains or lines available
Original:  J:125164 Gorrini C, et al., Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007 Aug 30;448(7157):1063-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory