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Ptf1atm1Mgn
Targeted Allele Detail
Nomenclature
Symbol: Ptf1atm1Mgn
Name: pancreas specific transcription factor, 1a; targeted mutation 1, Mark A Magnuson
MGI ID: MGI:3526067
Synonyms: Ptf1aLCA
Gene: Ptf1a  Location: Chr2:19445663-19447501 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Unknown
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, RMCE-ready)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a floxed neo cassette. This insertion results in the loxed cassette acceptor (LCA) available for recombinase mediated cassette exchange (RMCE). (J:135698)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  14 strains or lines available
References
Original:  J:135698 Burlison JS, et al., Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol. 2008 Apr 1;316(1):74-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory