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Kcna2tm1Tem
Targeted Allele Detail
Nomenclature
Symbol: Kcna2tm1Tem
Name: potassium voltage-gated channel, shaker-related subfamily, member 2; targeted mutation 1, Bruce L Tempel
MGI ID: MGI:3526017
Gene: Kcna2  Location: Chr3:107101146-107115005 bp, + strand  Genetic Position: Chr3, 46.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131735
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the entire open reading frame. mRNAQ cannot be found by quantitative PCR and protein product cannot be identified by Western blot in extracts from homozygous mutant mice. (J:131735)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcna2 Mutation:  19 strains or lines available
References
Original:  J:131735 Brew HM, et al., Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. J Neurophysiol. 2007 Sep;98(3):1501-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory