Lcn2^tm1Aade
Targeted Allele Detail

Summary

• Symbol: Lcn2^tm1Aade
• Name: lipocalin 2; targeted mutation 1, Alan Aderem
• MGI ID: MGI:3525578
• Synonyms: Lcn2^-
• Gene: Lcn2 Location: Chr2:32274649-32277751 bp, - strand Genetic Position: Chr2, 22.09 cM, cytoband A3
• Alliance: Lcn2^tm1Aade page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95107
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced coding exons 2-5. Absence of transcript was demonstrated by Northern blot analysis of mutant peritoneal macrophages. Immunoblot of mutant cell lysates confirmed the lack of protein. (J:95107)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lcn2^tm1Aade

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lcn2 Mutation: 27 strains or lines available

References

• Original: J:95107 Flo TH, et al., Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004 Dec 16;432(7019):917-21
• All: 105 reference(s)