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Targeted Allele Detail
Symbol: Mapk14tm1.1Otsu
Name: mitogen-activated protein kinase 14; targeted mutation 1.1, Kinya Otsu
MGI ID: MGI:3525575
Synonyms: p38alpha-
Gene: Mapk14  Location: Chr17:28691342-28748405 bp, + strand  Genetic Position: Chr17, 14.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:95116
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre mediated excision deleted the exon encoding part of the catalytic domain and the ATP binding loop (amino acids 40-83). (J:95116)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  29 strains or lines available
Original:  J:95116 Nishida K, et al., p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec;24(24):10611-20
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory