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Btg2tm1Spo
Targeted Allele Detail
Nomenclature
Symbol: Btg2tm1Spo
Name: B cell translocation gene 2, anti-proliferative; targeted mutation 1, S Paul Oh
MGI ID: MGI:3525505
Synonyms: Btg2-, PC3/Tis21-
Gene: Btg2  Location: Chr1:134075170-134079120 bp, - strand  Genetic Position: Chr1, 58.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95124
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 2, which contains sequence encoding APRO homology boxes A and B. Northern blot demonstrated the lack of transcript in mutant kidney samples. (J:95124)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btg2 Mutation:  5 strains or lines available
References
Original:  J:95124 Park S, et al., B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling. Mol Cell Biol. 2004 Dec;24(23):10256-62
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory