Idd23^NOD
QTL Variant Detail

Summary

• QTL variant: Idd23^NOD
• Name: insulin dependent diabetes susceptibility 23; NOD
• MGI ID: MGI:3525334
• QTL: Idd23 Location: Chr17:3974890-26401133 bp Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: NOD

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94603

Three loci showing linkage to type I diabetes on mouse Chromosome 17 were mapped using several subcongenic lines. The congenic lines were constructed using C57BL/6J donor derived regions introgressed onto a NOD genetic background. The diabetes loci are separate and distinct from the H2 locus.

Idd16 maps between D17Mit100 (11.75 cM) and D17Mit101 (16.4 cM). C57BL/6J-derived alleles confer resistance to type I diabetes with dominant inheritance at this locus. The Idd16 region is estimated to be 3.1 Mb in length. Potential candidate genes mapping near Idd16 are Mapk13 and Mapk14. A region of human Chromosome 6 (D6S291) syntenic to the mouse Idd16 region shows linkage to type I diabetes in a Scandinavian population.

Idd23 maps to a region between D17Mit164 (4.1 cM) and D17Mit100 (11.75 cM). This locus may be up to 20 Mb in length. C57BL/6J-derived alleles appear to confer a recessive protective effect at Idd23.

The third locus, provisionally designated Idd24, maps to an interval between Lta (19 cM) and D17Mit105 (21.95 cM). Authors state that follow up and confirmation of Idd24 should be performed.

References

• Original: J:94603 Deruytter N, et al., Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice. Diabetes. 2004 Dec;53(12):3323-7
• All: 1 reference(s)