Gp2^tm1Awl
Targeted Allele Detail

Summary

• Symbol: Gp2^tm1Awl
• Name: glycoprotein 2 zymogen granule membrane; targeted mutation 1, Anson W Lowe
• MGI ID: MGI:3525203
• Synonyms: Gp2^-
• Gene: Gp2 Location: Chr7:119041760-119058495 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Gp2^tm1Awl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95044
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 2-5, sequence encoding amino acids 1-282, with a neomycin resistance cassette. RT-PCR confirmed the absence of transcript in mutant pancreas. (J:95044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp2 Mutation: 42 strains or lines available

References

• Original: J:95044 Yu S, et al., Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion. J Biol Chem. 2004 Nov 26;279(48):50274-9
• All: 1 reference(s)