Nomenclature |
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Transgene origin |
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Transgene description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Disease models |
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Expression |
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Find Mice (IMSR) |
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Notes |
On an FVB/N genetic background, transgenic mice also carrying Tg(Myh6-tTA)6Smbf express Ro1 in the heart. Administration of the drug spiradoline results in a dramatic decrease of heart rate in these mice. X-gal staining of tissues from these mice reveals the pattern of cells that the tet system is working in. Ro1 activates Gi-signaling in response to spiradoline.
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO) |
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last database update 04/06/2021 MGI 6.16 |
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