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Prkcetm1Bai
Targeted Allele Detail
Nomenclature
Symbol: Prkcetm1Bai
Name: protein kinase C, epsilon; targeted mutation 1, Gottfried Baier
MGI ID: MGI:3524969
Synonyms: PKCepsilon-
Gene: Prkce  Location: Chr17:86167785-86657919 bp, + strand  Genetic Position: Chr17, 56.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94663
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted into exon 1. Immunostaining confirmed the lack of protein in mutant thymocytes. Flow cytometry indicated that thymocyte numbers and development appeared to be unaffected by the mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:  6 strains or lines available
References
Original:  J:94663 Gruber T, et al., Protein kinase Cvarepsilon is dispensable for TCR/CD3-signaling. Mol Immunol. 2005 Feb;42(3):305-310
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory