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Arigm5NZB/BlNJ
QTL Variant Detail
Summary
QTL variant: Arigm5NZB/BlNJ
Name: anti-RBC IgM antibodies 5; NZB/BlNJ
MGI ID: MGI:3524934
QTL: Arigm5  Location: unknown  Genetic Position: Chr12, Syntenic
Variant
origin
Strain of Specimen:  NZB/BlNJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased anti-RBC IgM antibodies at 6 months of age compared to BALB/cByJ. (J:93737)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93737

Linkage analysis was performed on 222 female animals from a (NZB/BlNJ x BALB/cByJ)F2 intercross to identify QTLs associated with susceptibility to autoimmune hemolytic anemia (AHA) and systemic lupus erythematosus (SLE). 96 polymorphic markers at an average spacing of 17 cM were used in the genome scan. Parental strain NZB/BlNJ is susceptible to autoimmune hemolytic anemia and exhibits elevated serum levels of anti-red blood cell antibodies compared to BALB/cByJ. NZB/BlNJ is also susceptible to systemic lupus erythematosus and exhibits elevated serum levels of antinuclear antibodies compared to parental strain BALB/cByJ.

On mouse Chromosome 12, linkage to anti-red blood cell IgM antibodies at 6 months of age mapped to 1 cM (P=4.5 x 10-3). This locus is named Arigm5 (anti-RBC IgM antibodies 5). Linkage to anti-red blood cell IgM antibodies at 8 months of age also mapped to 1 cM (P=7.8 x 10-4). This locus is named Arigm6. NZB/BlNJ-derived alleles confer increased IgM antibodies at Arigm5 and Arigm6.

References
Original:  J:93737 Lee NJ, et al., Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action. Clin Exp Immunol. 2004 Oct;138(1):39-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory