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Slc6a8tm1.2Clar
Targeted Allele Detail
Nomenclature
Symbol: Slc6a8tm1.2Clar
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.2, Joseph Clark
MGI ID: MGI:3522510
Gene: Slc6a8  Location: ChrX:73673150-73682502 bp, + strand  Genetic Position: ChrX, 37.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169472
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination of Slc6a8tm1.1Clar removed exons 2, 3, and 4. (J:169472)
Generation of the Slc6a8tm1Clar, Slc6a8tm1.1Clar, and Slc6a8tm1.2Clar alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a8 Mutation:  6 strains or lines available
References
Original:  J:169472 Skelton MR, et al., Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PLoS One. 2011;6(1):e16187
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory