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Targeted Allele Detail
Symbol: Als2tm1Cai
Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Huaibin Cai
MGI ID: MGI:3522476
Synonyms: ALS2-
Gene: Als2  Location: Chr1:59162926-59237231 bp, - strand  Genetic Position: Chr1, 29.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:100336
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 39 bp BamHI fragment in the 1st coding exon of ALS2 was replaced with a lacZ gene and selection marker flanked with loxP sites. QPCR and Western blot analysis confirmed the absence of transcription and translation. (J:100336)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Als2 Mutation:  60 strains or lines available
Original:  J:100336 Cai H, et al., Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci. 2005 Aug 17;25(33):7567-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory