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Targeted Allele Detail
Symbol: Cdh2tm1Glr
Name: cadherin 2; targeted mutation 1, Glenn L Radice
MGI ID: MGI:3522469
Synonyms: N-cadflox
Gene: Cdh2  Location: Chr18:16588877-16809246 bp, - strand  Genetic Position: Chr18, 10.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:98828
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1, which contains the translational start site and upstream transcriptional regulatory sequences, was flanked with loxP sites. An FRT-flanked neomycin selection cassette was inserted into intron 1 and subsequently removed by crossing with mice expressing FLP recombinase in the germline. (J:98828)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh2 Mutation:  17 strains or lines available
Original:  J:98828 Kostetskii I, et al., Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res. 2005 Feb 18;96(3):346-54
All:  29 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory