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Ppargc1atm1Dpk
Targeted Allele Detail
Nomenclature
Symbol: Ppargc1atm1Dpk
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Daniel P Kelly
MGI ID: MGI:3522468
Synonyms: PGC-1alpha-
Gene: Ppargc1a  Location: Chr5:51454249-51567725 bp, - strand  Genetic Position: Chr5, 27.02 cM, cytoband C1
Hepatic steatosis develops in fasted Ppargc1atm1Dpk/Ppargc1atm1Dpk mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96306
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Other
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppargc1a Mutation:  7 strains or lines available
References
Original:  J:96306 Leone TC, et al., PGC-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. PLoS Biol. 2005 Mar 15;3(4):e101
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory