About   Help   FAQ
Targeted Allele Detail
Symbol: Ppargc1atm1Dpk
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 1, Daniel P Kelly
MGI ID: MGI:3522468
Synonyms: PGC-1alpha-
Gene: Ppargc1a  Location: Chr5:51454250-51567726 bp, - strand  Genetic Position: Chr5, 27.02 cM, cytoband C1
Hepatic steatosis develops in fasted Ppargc1atm1Dpk/Ppargc1atm1Dpk mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:96306
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Other
Mutation detailsThe targeting event for this knock-out resulted in a 3 prime end recombination and an insertion on the 5 prime end causing an additional exon 3 in the allele downstream of exon 5. This additional exon 3 causes a premature stop codon at amino acid 255 and an unstable transcript (no smaller proteins were identified by Western blot analysis). RT-PCR, Northern and Western blot analysis confirmed the absence of a stable transcript and no detectable protein. (J:96306)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppargc1a Mutation:  9 strains or lines available
Original:  J:96306 Leone TC, et al., PGC-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis. PLoS Biol. 2005 Mar 15;3(4):e101
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory