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Targeted Allele Detail
Symbol: Kcnn2tm1.1Jpad
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; targeted mutation 1.1, John P Adelman
MGI ID: MGI:3522425
Synonyms: SK2delta
Gene: Kcnn2  Location: Chr18:45401927-45819091 bp, + strand  Genetic Position: Chr18, 24.34 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:94941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted 300 nucleotides 5' of the initiation methionine codon in exon 1 and a floxed neomycin resistance gene as well as an EGFP gene were inserted in intron 2. Crossing to cre-deleter mice led to the excision of the the coding portion of exon 1 and exon 2 as well as the neo resistance gene. RT-PCR and Western blot analysis confirmed the absence of transcription and translation. The EGFP insert was non functional. (J:94941)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnn2 Mutation:  28 strains or lines available
Original:  J:94941 Bond CT, et al., Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci. 2004 Jun 9;24(23):5301-6
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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