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Targeted Allele Detail
Symbol: Npbwr1tm1Rck
Name: neuropeptides B/W receptor 1; targeted mutation 1 Jeffrey M Friedman
MGI ID: MGI:3522352
Synonyms: Gpr7-
Gene: Npbwr1  Location: Chr1:5913707-5917398 bp, - strand  Genetic Position: Chr1, 1.89 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:94820
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P/Ola
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn IRES-tau-EGFP cassette was inserted into the single coding exon. Northern blot of mutant hypothalamus showed the presence of a transcript increased by 6 kb compared to wild-type, confirming the insertion of the cassette. (J:94820)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npbwr1 Mutation:  13 strains or lines available
Original:  J:94820 Ishii M, et al., Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10540-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory