Lama2^tm1Eeng
Targeted Allele Detail

Summary

• Symbol: Lama2^tm1Eeng
• Name: laminin, alpha 2; targeted mutation 1, Eva Engvall
• MGI ID: MGI:3522319
• Synonyms: dy^w, Lama2^-, Lama2^dy-W
• Gene: Lama2 Location: Chr10:26857281-27493021 bp, - strand Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
• Alliance: Lama2^tm1Eeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49435
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a lacZ and neomycin resistance cassette 23 bp downstream of the ATG start site disrupts gene transcription. (J:48073, J:49435)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lama2 Mutation: 177 strains or lines available

References

• Original: J:49435 Kuang W, et al., Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models. J Clin Invest. 1998 Aug 15;102(4):844-52
• All: 32 reference(s)