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Lama2tm1Eeng
Targeted Allele Detail
Nomenclature
Symbol: Lama2tm1Eeng
Name: laminin, alpha 2; targeted mutation 1, Eva Engvall
MGI ID: MGI:3522319
Synonyms: dyw, Lama2-, Lama2dy-W
Gene: Lama2  Location: Chr10:26980036-27619758 bp, - strand  Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49435
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsInsertion of a lacZ and neomycin resistance cassette 23 bp downstream of the ATG start site disrupts gene transcription. (J:48073, J:49435)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lama2 Mutation:  93 strains or lines available
References
Original:  J:49435 Kuang W, et al., Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models. J Clin Invest. 1998 Aug 15;102(4):844-52
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory