Tg(Gfap-cre)73.12Mvs
Transgene Detail

Summary

• Symbol: Tg(Gfap-cre)73.12Mvs
• Name: transgene insertion 73.12, Michael V Sofroniew
• MGI ID: MGI:3522215
• Synonyms: GFAP-Cre, mGFAP^Cre, mGFAP-Cre
• Transgene: Tg(Gfap-cre)73.12Mvs Location: unknown
• Alliance: Tg(Gfap-cre)73.12Mvs page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6NHsd)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gfap-cre)73.12Mvs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gfap (MGI:95697)

• Mutation details: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. (J:94543)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gfap (mouse) Summary of all recombinase alleles driven by Gfap. Comparative matrix view of recombinase activities Alliance mouse Gfap gene page

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:94543 Garcia AD, et al., GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci. 2004 Nov;7(11):1233-41
• All: 99 reference(s)