Srf^tm1Rmn
Targeted Allele Detail

Summary

• Symbol: Srf^tm1Rmn
• Name: serum response factor; targeted mutation 1, Narendrakumar Ramanan
• MGI ID: MGI:3522206
• Synonyms: Srf^f, Srf^fl, Srf^tm1Ddg, Srf^tm1Jomm
• Gene: Srf Location: Chr17:46859255-46867101 bp, - strand Genetic Position: Chr17, 22.9 cM
• Alliance: Srf^tm1Rmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94725
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the promoter and exon 1, the region containing key regulatory elements important for promoter activity as well as many of the DNA-binding and dimerization residues. (J:94725, J:99232)

Expression

In Mice Carrying this Mutation:	22 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srf Mutation: 25 strains or lines available

References

• Original: J:94725 Miano JM, et al., Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7
• All: 51 reference(s)