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Srftm1Rmn
Targeted Allele Detail
Nomenclature
Symbol: Srftm1Rmn
Name: serum response factor; targeted mutation 1, Narendrakumar Ramanan
MGI ID: MGI:3522206
Synonyms: Srff, Srffl, Srftm1Ddg, Srftm1Jomm
Gene: Srf  Location: Chr17:46859255-46867101 bp, - strand  Genetic Position: Chr17, 22.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94725
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank the promoter and exon 1, the region containing key regulatory elements important for promoter activity as well as many of the DNA-binding and dimerization residues. (J:94725, J:99232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srf Mutation:  16 strains or lines available
References
Original:  J:94725 Miano JM, et al., Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17132-7
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory