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Etan1C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Etan1C57BL/6J
Name: ether anesthesia 1; C57BL/6J
MGI ID: MGI:3522106
QTL: Etan1  Location: unknown  Genetic Position: Chr7, cM position of peak correlated region/allele: 43.46 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to ether anesthesia compared to MSM/Ms. (J:94250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94250

Linkage analysis was performed on 196 (C57BL/6J x MSM/Ms)F1 x MSM/Ms backcross animals to identify QTLs influencing sensitivity to ether anesthesia. Parental strain C57BL/6J exhibits resistance to ether anesthesia whereas parental strain MSM/Ms is sensitive. (C57BL/6J x MSM/Ms)F1 hybrids are resistant to ether anesthesia. An initial screen was done with 40 microsatellite markers using 12 resistant and 12 sensitive backcross animals. Linkage was detected on mouse Chromosomes 3, 7, and 8. More markers weretyped in the remaining animals and mouse Chromosome 7 showed the strongest linkage between 23 cM (D7Mit313) and 29 cM (D7Nds1). Peak linkage occurred near D7Nds1 with LOD=3.03. This locus is named Etan1 (ether anesthesia 1). Animals heterozygous at Etan1 are resistant to ether anesthesia compared animals homozygous for MSM/Ms-derived alleles. Potential candidate genes mapping near Etan1 are Gabrg3 (28.2 cM), Gabra5 (28.5 cM), Gabrb2 (28.6 cM), and Chrna7 (30 cM).

References
Original:  J:94250 Megumi T, et al., Mapping of putative ether-anesthesia resistance gene using C57BL/6J and MSM/Ms mouse strains. J Anesth. 2004;18(4):267-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory