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Mmp13tm1.1Werb
Targeted Allele Detail
Nomenclature
Symbol: Mmp13tm1.1Werb
Name: matrix metallopeptidase 13; targeted mutation 1.1, Zena Werb
MGI ID: MGI:3521938
Synonyms: Mmp13-
Gene: Mmp13  Location: Chr9:7272514-7283331 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94460
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3-5 were replaced with a single loxP site following homologous recombination and subsequent Cre-mediated excision of the floxed segment. Western blot showed that no protein was created in the mutant mice. (J:94460)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp13 Mutation:  17 strains or lines available
References
Original:  J:94460 Stickens D, et al., Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development. 2004 Dec;131(23):5883-95
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory