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Serpini2pq
Transgenic Allele Detail
Nomenclature
Symbol: Serpini2pq
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2; pequeno
MGI ID: MGI:3521922
Gene: Serpini2  Location: Chr3:75242370-75270078 bp, - strand  Genetic Position: Chr3, 33.74 cM
Runted size and acinar cell loss in Serpini2pq/Serpini2pq mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic
Mutation:    Intergenic deletion
 
Mutation detailsRandom transgene insertion leading to an approximately 210-kb deletion which includes the entire Serpini2 gene and several 3' exons of Ensembl-predicted novel gene transcript sequences ENSMUST00000062199.1 and ENSMUST00000038943.1. BAC transgene complementation demonstrated that Serpini2 deletion is responsible for the phenotype. (J:115744)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpini2 Mutation:  12 strains or lines available
References
Original:  J:115744 Loftus SK, et al., Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLoS Genet. 2005 Sep;1(3):e38
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory