Sat1^tm1Alh
Targeted Allele Detail

Summary

• Symbol: Sat1^tm1Alh
• Name: spermidine/spermine N1-acetyl transferase 1; targeted mutation 1, Leena Alhonen
• MGI ID: MGI:3521903
• Synonyms: SSAT-ko
• Gene: Sat1 Location: ChrX:153996128-153999445 bp, - strand Genetic Position: ChrX, 72.38 cM, cytoband F3-F4
• Alliance: Sat1^tm1Alh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99381
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A SmaI fragment containing part of exon 1 was replaced with a neomycin resistance cassette. Western blot analysis indicated the absence of protein product. (J:77802)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sat1 Mutation: 7 strains or lines available

References

• Original: J:99381 Tucker JM, et al., Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res. 2005 Jun 15;65(12):5390-8
• All: 12 reference(s)