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HmdcC3H/HeJ
QTL Variant Detail
Nomenclature
QTL variant: HmdcC3H/HeJ
Name: heterogeneity of muscle Gapd decay constants; C3H/HeJ
MGI ID: MGI:3521881
QTL: Hmdc  Location: unknown  Genetic Position: Chr5, cM position of peak correlated region/allele: 47.29 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C3H/HeJ
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased heterogeneity of muscle Gapd decay constants compared to DBA/2J. (J:94275)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94275

600 animals from a four-way cross between (BALB/cJ x C57BL/6J)F1 x (C3H/HeJ x DBA/2J)F1 were analyzed for QTLs associated with age-related biophysical traits. 99 polymorphic markers at an average spacing of 15 cM - 20 cM were used in the genome scan. Animals were 18 months old at time of analysis.

A locus on mouse Chromosome 5 shows linkage to muscle Gapd decay rate at 26 cM near D5Mit79 (P<0.001) and is named Mgdr1 (muscle Gapd decay rate 1). (The Gapd decay rate decreases with age.) A second locus at 12 cM near D5Mit251 (P<0.001) also shows linkage to muscle Gapd decay rate and is named Mgdr2. The C3H/HeJ-derived allele confers increased muscle Gapd decay rates at both QTLs compared to the DBA/2J allele. A locus at 45 cM shows linkage to heterogeneity of muscle Gapd decay constants near D5Mit205 (P<0.024). This locus is named Hmdc (heterogeneity of muscle Gapd decay constants). The C3H/HeJ-derived allele confers increased heterogeneity compared to the DBA/2J allele. A locus at 61 cM near D5Mit25 (P<0.03) shows linkage to eye lens protein fluorescence emission ratio. (The fluorescence emission ratio decreases with age.) This locus is named Elpfm (eye lens protein fluorescence emission). The C3H/HeJ-derived allele confers increased eye lens protein fluorescence emission ratio compared to the DBA/2J allele.

Two loci on mouse Chromosome 15 named Lgdr1 (liver Gapd decay rate 1) and Lgdr2 show linkage to liver Gapd decay rate at 21 cM near D15Mit100 (P<0.006) and at 29 cM near D15Mit63 (P<0.006), respectively. (The Gapd decay rate decreases with age.) BALB/cJ-derived alleles confer increased liver Gapd decay rates at both QTLs compared to the C57BL/6J allele. A locus at 55 cM near D15Mit171 (P<0.04) shows linkage to the amount of protein extracted from eye lens. Eye lens protein decreases with age as the protein become insoluble. This locus is named Ablp (absorbance of eye lens protein). BALB/cJ-derived alleles confer increased eye lens protein compared to the C57BL/6J allele.

A locus at 71 cM on mouse Chromosome 8 near D8Mit42 (P<0.04) shows linkage to the heterogeneity in eye lens protein photooxidation kinetics. This locus is named Hlpx (heterogeneity in eye lens protein photooxidation kinetics). The C3H/HeJ-derived allele confers increased standard error compared to the DBA/2J allele.

References
Original:  J:94275 Wisser KC, et al., Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function. Arch Biochem Biophys. 2004 Dec 1;432(1):58-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory