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Erbb2tm7(Erbb2)Mul
Targeted Allele Detail
Summary
Symbol: Erbb2tm7(Erbb2)Mul
Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 7, William J Muller
MGI ID: MGI:3521860
Synonyms: Erbb2Y1227F
Gene: Erbb2  Location: Chr11:98303310-98328542 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Erbb2tm7(Erbb2)Mul page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94397
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Erbb2tm7(Erbb2)Mul expresses 1 gene
 
Mutation detailsA targeting vector was designed to replace the first coding exon with the rat Erbb2 cDNA with the Y1227F mutation, resulting in the loss of the direct binding site for Shc1. A neo was also inserted. Analysis of the RT-PCR product indicated that mutants only expressed the rat cDNA. (J:94397)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  59 strains or lines available
References
Original:  J:94397 Chan R, et al., Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004 Nov;131(22):5551-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory