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Igf2tm3Wrk
Targeted Allele Detail
Nomenclature
Symbol: Igf2tm3Wrk
Name: insulin-like growth factor 2; targeted mutation 3, Wolf Reik
MGI ID: MGI:3521799
Synonyms: deltaDMR2, Igf2tm3Wrk-mat, Igf2tm3Wrk-pat
Gene: Igf2  Location: Chr7:142650766-142666816 bp, - strand  Genetic Position: Chr7, 87.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94521
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 54 bp core region of DMR2 (CpG18-CpG25), in exon 6, was deleted in frame following the insertion and subsequent Cre-mediated deletion of a floxed neo. This sequence encodes the E peptide or C-terminal propeptide domain of prepro-Igf2. (J:94521)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2 Mutation:  10 strains or lines available
Notes
ES cell line = CGR.
References
Original:  J:94521 Murrell A, et al., An intragenic methylated region in the imprinted Igf2 gene augments transcription. EMBO Rep. 2001 Dec;2(12):1101-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory