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Kcnn4tm1Jemn
Targeted Allele Detail
Nomenclature
Symbol: Kcnn4tm1Jemn
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1, James E Melvin
MGI ID: MGI:3521668
Synonyms: IK1-, KCa3.1, KCa3.1-, Kcnn4-
Gene: Kcnn4  Location: Chr7:24370263-24386690 bp, + strand  Genetic Position: Chr7, 10.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94478
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was deleted upon incorporation of a PGK-neo cassette into the locus. Northern blot showed a lack of transcript in mutant CD4+ T lymphocytes. (J:94478)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnn4 Mutation:  6 strains or lines available
References
Original:  J:94478 Begenisich T, et al., Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12;279(46):47681-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory