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Hap1tm1Id
Targeted Allele Detail
Nomenclature
Symbol: Hap1tm1Id
Name: huntingtin-associated protein 1; targeted mutation 1, Ioannis Dragatsis
MGI ID: MGI:3521576
Gene: Hap1  Location: Chr11:100347327-100356128 bp, - strand  Genetic Position: Chr11, 63.47 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94581
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA targeting vector was designed to replace 5 kb of sequence containing the promoter, exon 1 and a portion of intron 1 with a neo cassette placed in opposite orientation of transcription. Northern blot indicated the absence of transcript in mutant neonatal mouse brains. (J:94581)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hap1 Mutation:  22 strains or lines available
References
Original:  J:94581 Dragatsis I, et al., Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation. Hum Mol Genet. 2004 Dec 15;13(24):3115-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory