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Spout1tm1Mxu
Targeted Allele Detail
Nomenclature
Symbol: Spout1tm1Mxu
Name: SPOUT domain containing methyltransferase 1; targeted mutation 1, Ming Xu
MGI ID: MGI:3514265
Synonyms: EndoG-, Endogtm1Mxu
Gene: Spout1  Location: Chr2:30173453-30178459 bp, - strand  Genetic Position: Chr2, 21.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88144
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe majority of the 3 exons of the Endog and 5 of 10 exons of D2Wsu81e (which overlaps exon 3 of Endog) were replaced with a neomycin selection cassette inserted by homologous recombination. Reduced ENDOG protein levels were detected by Western blot analysis of protein extracts obtained from heterozygous MEFs and hearts. (J:88144, J:94752)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spout1 Mutation:  8 strains or lines available
References
Original:  J:88144 Zhang J, et al., Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15782-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory