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Nde1tm1Caw
Targeted Allele Detail
Nomenclature
Symbol: Nde1tm1Caw
Name: nudE neurodevelopment protein 1; targeted mutation 1, Christopher A Walsh
MGI ID: MGI:3514026
Synonyms: Nde1-
Gene: Nde1  Location: Chr16:14163275-14192928 bp, + strand  Genetic Position: Chr16, 9.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94756
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a floxed PGK-neomycin cassette was inserted downstream. Transient transfection of properly targeted ES cells with a Cre-expressing plasmid resulted in excision of the selection cassette together with exon 2. Immunoblot analysis confirmed the absence of protein product. (J:94756)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nde1 Mutation:  24 strains or lines available
References
Original:  J:94756 Feng Y, et al., Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004 Oct 14;44(2):279-93
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory