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Rgs14tm1Pngr
Targeted Allele Detail
Nomenclature
Symbol: Rgs14tm1Pngr
Name: regulator of G-protein signaling 14; targeted mutation 1, Josef M Penninger
MGI ID: MGI:3514019
Gene: Rgs14  Location: Chr13:55369732-55384687 bp, + strand  Genetic Position: Chr13, 29.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94516
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 9, including the those encoding the RGS-box, were replaced with a PGK-neo construct via homologous recombination. Immunofluorescence confirmed the absence of protein in 1-cell stage zygotes. (J:94516)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs14 Mutation:  18 strains or lines available
References
Original:  J:94516 Martin-McCaffrey L, et al., RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 2004 Nov;7(5):763-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory