Endog^tm1Mili
Targeted Allele Detail

Summary

• Symbol: Endog^tm1Mili
• Name: endonuclease G; targeted mutation 1, Michael R Lieber
• MGI ID: MGI:3514015
• Synonyms: endo G^-
• Gene: Endog Location: Chr2:30061525-30064057 bp, + strand Genetic Position: Chr2, 21.29 cM, cytoband B
• Alliance: Endog^tm1Mili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94752
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin resistance cassette. Absence of protein product was confirmed by Western blot analysis. This allele does not disrupt a downstream gene in reverse orientation that overlaps exon 3 and part of intron 2. (J:94752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Endog Mutation: 11 strains or lines available

References

• Original: J:94752 Irvine RA, et al., Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan;25(1):294-302
• All: 6 reference(s)