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Htr5atm1Rhn
Targeted Allele Detail
Nomenclature
Symbol: Htr5atm1Rhn
Name: 5-hydroxytryptamine (serotonin) receptor 5A; targeted mutation 1, Rene Hen
MGI ID: MGI:3513844
Synonyms: 5A-KO
Gene: Htr5a  Location: Chr5:27842149-27855088 bp, + strand  Genetic Position: Chr5, 13.24 cM, cytoband A3-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54098
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace 23% of the coding sequence, including the first and second transmembrane domains, with a neomycin resistance gene. A lack of transcript as shown by Northern blot of brain tissues confirmed successful targeting. (J:54098)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr5a Mutation:  10 strains or lines available
References
Original:  J:54098 Grailhe R, et al., Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999 Mar;22(3):581-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory