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Targeted Allele Detail
Symbol: Slc7a1tm1Rbmn
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; targeted mutation 1, Robert A Bosselman
MGI ID: MGI:3513834
Synonyms: mCAT-1-
Gene: Slc7a1  Location: Chr5:148327410-148399904 bp, - strand  Genetic Position: Chr5, 88.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:39649
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo replaced exon 4 by homologous recombination. Exon 4 encodes the YGE residues required for virus binding. Successful disruption of the gene was confirmed by XC fusion assay and mRNA was negative for amino acid transport activity. (J:39649)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc7a1 Mutation:  80 strains or lines available
ES cell line = E14K (129P2/OlaHsd) or W9.5 (129S1/Sv-p+ Tyr+ Kitl+).
Original:  J:39649 Perkins CP, et al., Anemia and perinatal death result from loss of the murine ecotropic retrovirus receptor mCAT-1. Genes Dev. 1997 Apr 1;11(7):914-25
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory