About   Help   FAQ
Apctm1Cip
Targeted Allele Detail
Nomenclature
Symbol: Apctm1Cip
Name: adenomatosis polyposis coli; targeted mutation 1, Christine Perret
MGI ID: MGI:3513416
Synonyms: Apcdelta14
Gene: Apc  Location: Chr18:34220924-34318608 bp, + strand  Genetic Position: Chr18, 18.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94108
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 13 and a loxP flanked PGK-Hprt cassette into intron 14. Crossing with transgenic mice expressing Cre in the germline excised exon 14 and the Hprt cassette. RT-PCR indicated the lack of transcript in colon samples from mutants. (J:94108)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  100 strains or lines available
References
Original:  J:94108 Colnot S, et al., Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest. 2004 Dec;84(12):1619-30
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory